Author's response to reviews Title: Oral intake of Phenylbutyrate and vitamin D3 upregulates the Cathelicidin LL-37 in human macrophages: A dose finding study for treatment of tuberculosis Authors:
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چکیده
Title: Oral intake of Phenylbutyrate and vitamin D3 upregulates the Cathelicidin LL-37 in human macrophages: A dose finding study for treatment of tuberculosis Authors: Akhirunnesa Mily ([email protected]) Rokeya Sultana Rekha ([email protected]) SM Mostafa Kamal ([email protected]) Evana Akhtar ([email protected]) Protim Sarker ([email protected]) Zeaur Rahim ([email protected]) Gudmundur H. Gudmundsson ([email protected]) Birgitta Agerbeth ([email protected]) Rubhana Raqib ([email protected])
منابع مشابه
Oral intake of phenylbutyrate with or without vitamin D3 upregulates the cathelicidin LL-37 in human macrophages: a dose finding study for treatment of tuberculosis
BACKGROUND We earlier showed that 4-phenylbutyrate (PB) can induce cathelicidin LL-37 expression synergistically with 1,25-dihydroxyvitamin D3 in a lung epithelial cell line. We aimed to evaluate a therapeutic dose of PB alone or in combination with vitamin D3 for induction of LL-37 expression in immune cells and enhancement of antimycobacterial activity in monocyte-derived macrophages (MDM). ...
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Adjunctive vitamin D treatment for pulmonary tuberculosis enhances resolution of inflammation but has modest effects on bacterial clearance. Sodium 4-phenylbutyrate (PBA) is in clinical use for a range of conditions and has been shown to synergise with vitamin D metabolites to upregulate cathelicidin antimicrobial peptide (CAMP) expression. We investigated whether clinically attainable plasma c...
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BACKGROUND Development of new tuberculosis (TB) drugs and alternative treatment strategies are urgently required to control the global spread of TB. Previous results have shown that vitamin D3 (vitD3) and 4-phenyl butyrate (PBA) are potent inducers of the host defense peptide LL-37 that possess anti-mycobacterial effects. OBJECTIVE To examine if oral adjunctive therapy with 5,000IU vitD3 or 2...
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Tuberculosis (TB) is a major global health problem. Patients with TB have a high rate of vitamin D deficiency, both at diagnosis and during the course of treatment with anti-tuberculosis drugs. Although data on the efficacy of vitamin D supplementation on Mycobacterium tuberculosis (Mtb) clearance is uncertain from randomized controlled trials (RCTs), vitamin D enhances the expression of the an...
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Background Rotavirus is the most prevalent cause of severe gastroenteritis, hospitalizations, and deaths among infants and young children, globally. No specific antiviral drug is available against rotavirus infection. Objective The current study aimed to assess the antiviral effect of human cathelicidin antimicrobial peptide LL-37 on rotavirus infection in vitro. Methods This study was con...
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